●オキシヘモグロビンとデオキシヘモグロビン 初期表示はデオキシヘモグロビンの2HHB;4量体
●いろいろな生物のヘモグロビンデータほか 初期表示はマンモス由来ヘモグロビン3VRF;2量体 ※その他参考:Jmolトピック
●アミノ色表示の凡例
ASP GLU CYS MET LYS ARG SER THR PHE TYR ASN GLN GLY LEU VAL ILE ALA TRP HIS PRO
●酸性・中性〈芳香族〉・塩基性アミノ酸区別表示の凡例
ASP GLU GLY ALA VAL LEU ILE CYS SER THR ASN GLN PRO MET PHE TYR TRP LYS ARG HIS
●極性〈酸性・塩基性〉・非極性(疎水性)アミノ酸区別
SER THR TYR CYS ASN GLN ASP GLU LYS ARG HIS GLY ALA VAL LEU ILE PHE PRO MET TRP
●疎水性インデックス順
ARG LYS ASN ASP GLN GLU HIS PRO TYR TRP SER THR GLY ALA MET CYS PHE LEU VAL ILE
●有機概念図I/O値順(特性基 R)
ASN SER ASP GLN GLU THR ARG HIS GLY LYS TYR TRP CYS MET PRO PHE ALA VAL LEU ILE
●等電点順
ASP GLU CYS ASN PHE GLN TYR SER MET TRP VAL GLY LEU ALA ILE THR PRO HIS LYS ARG
アミノ酸および特性基の親水性・疎水性 | Log Pをポケットに!
オキシヘモグロビン1HHO(スティック表示)とデオキシヘモグロビン2HHB(針金表示)のPyMOLによる重ね合わせ表示(何れもChain AのPDBsumデータ)
※PyMOLによるPDBデータ重ね合わせ方法:中村春木 編,「見てわかる構造生命科学」,化学同人(2014),p.78
ヒトヘモグロビン2HHBとチューブワーム由来ヘモグロビン1YHUのPyMOLによる重ね合わせ表示(何れもChain A)
[左]3Dプリンタによるデオキシヘモグロビン2HHB(4量体)の分子模型 [右]4量体模型と「鍵と鍵穴」模型
※新分子模型Kawakami Modelに関する資料はこちらもご覧ください。
★本分子模型を使った出張講座・土曜講座の受け付けをしています。
〔左〕ヘモグロビンS2hbs B鎖,〔右〕ヘモグロビン4hhb B鎖
オキシヘモグロビン1HHO A鎖
同4量体(A・B鎖×2)
同4量体のPyMOLによる表示例
デオキシヘモグロビン2HHBの4量体
デオキシヘモグロビン2HHB Chain Bのヘム(HEM)近傍
デオキシヘモグロビン2HHBのPDBsumデータ(HEM)
デオキシヘモグロビン2HHBのHEM近傍His(〇印)
001-025 | Val | Leu | Ser | Pro | Ala | Asp | Lys | Thr | Asn | Val | Lys | Ala | Ala | Trp | Gly | Lys | Val | Gly | Ala | His | Ala | Gly | Glu | Tyr | Gly |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
026-050 | Ala | Glu | Ala | Leu | Glu | Arg | Met | Phe | Leu | Ser | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Leu | Ser | His |
051-075 | Gly | Ser | Ala | Gln | Val | Lys | Gly | His | Gly | Lys | Lys | Val | Ala | Asp | Ala | Leu | Thr | Asn | Ala | Val | Ala | His | Val | Asp | Asp |
076-100 | Met | Pro | Asn | Ala | Leu | Ser | Ala | Leu | Ser | Asp | Leu | His | Ala | His | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu |
101-125 | Leu | Ser | His | Cys | Leu | Leu | Val | Thr | Leu | Ala | Ala | His | Leu | Pro | Ala | Glu | Phe | Thr | Pro | Ala | Val | His | Ala | Ser | Leu |
126- | Asp | Lys | Phe | Leu | Ala | Ser | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg |
2HHB B鎖(ヘモグロビンβ;赤字がFe近傍His)
001-025 | Val | His | Leu | Thr | Pro | Glu | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
026-050 | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
051-075 | Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu |
076-100 | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
101-125 | Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro |
126- | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
4MQJ F鎖(胎児ヘモグロビンHbF,ヘモグロビンγ;赤字がFe近傍His)
001-025 | Val | His | Phe | Thr | Glu | Glu | Asp | Lys | Ala | Thr | Ile | Thr | Ser | Leu | Trp | Gly | Lys | Val | Asn | Val | Glu | Asp | Ala | Gly | Gly |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
026-050 | Glu | Thr | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Asp | Ser | Phe | Gly | Asn | Leu | Ser | Ser |
051-075 | Ala | Ser | Ala | Ile | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Thr | Ser | Leu | Gly | Asp | Ala | Ile |
076-100 | Lys | His | Leu | Asp | Asp | Leu | Lys | Gly | Thr | Phe | Ala | Gln | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
101-125 | Glu | Asn | Phe | Lys | Leu | Leu | Gly | Asn | Val | Leu | Val | Thr | Val | Leu | Ala | Ile | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Glu |
126- | Val | Gln | Ala | Ser | Trp | Gln | Lys | Met | Val | Thr | Gly | Val | Ala | Ser | Ala | Leu | Ser | Ser | Arg | Tyr | His |
Val | His | Leu | Thr | Pro | Glu | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
Val | His | Phe | Thr | Glu | Glu | Asp | Lys | Ala | Thr | Ile | Thr | Ser | Leu | Trp | Gly | Lys | Val | Asn | Val | Glu | Asp | Ala | Gly | Gly | Glu | Thr | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Asp | Ser | Phe | Gly | Asn | Leu | Ser | Ser |
Ala | Ser | Ala | Ile | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Thr | Ser | Leu | Gly | Asp | Ala | Ile | Lys | His | Leu | Asp | Asp | Leu | Lys | Gly | Thr | Phe | Ala | Gln | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Lys | Leu | Leu | Gly | Asn | Val | Leu | Val | Thr | Val | Leu | Ala | Ile | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Glu | Val | Gln | Ala | Ser | Trp | Gln | Lys | Met | Val | Thr | Gly | Val | Ala | Ser | Ala | Leu | Ser | Ser | Arg | Tyr | His |
CO結合カルボモノオキシヘモグロビンのヘム近傍PDBsumデータの比較(1AJ9と4MQC,何れもA鎖)
※V62M変異の4MQCは自己免疫性溶血性貧血のEvans症候群に関係すると考えられる。
一酸化炭素が結合した Ni(II)-Fe(II)混成ヘモグロビン6KAEのChain A-DとそのPDBsumデータ(Chain A〈CO結合〉・B) → Jmolトピック
※ヘモグロビンによるガス分子運搬の直接観察に成功(横浜市立大学,2020/02/18) …6KAE以外に6KA9・6KAH・6KAI・6KAO〜6KAV・6L5V〜6L5Y・6LCW・6LCX公開
ヒトヘモグロビン2HHBとマンモスヘモグロビン3VRFのPyMOLによる表示(何れもChain A)
ヘムのPDBsumデータの構成アミノ酸の違い(右はPDBsumデータ2hhb_HEM)
デオキシヘモグロビン3KMFのPDBsumデータ(A鎖HEM,PDBsumデータにH・D追加;中性子回折による座標)
参考:What is a Protein? - YouTube
参考:The flyer What is a Protein? (RCSB PDB) [PDF]
※数研出版「フォトサイエンス生物図録」,同「チャート式 新化学」,講談社ブルーバックス「動く分子事典」p.256なども参照。
※注:本アニメgif中の2次構造画像にはα-ヘリックスのみでβ-シートは含まれていません。他のJmolコンテンツをご参照ください。
【参考】いろいろな生物のヘモグロビンのアミノ酸配列比較
001-050
ヘモグロビンのアミノ酸配列比較例(付記がないものは何れもA鎖);ヒト(2hhb),ヒト胎児HbF(4mqj,B鎖;A鎖はヒトと同じ),マンモス(3vrf),ハツカネズミ(3hrw),ウズラ(3mjp),クロマグロ(1v4w),シロザメ(1gcw),ヤツメウナギ(2lhb),ヌタウナギ(1it3),チューブワーム(1yhu),マシコヒゲムシ(2d2n) → その他参考:Glossoscolex paulistusの巨大ヘモグロビン
ヘモグロビン構造の比較 [1](何れもA鎖): ヒト(2HHB,デオキシヘモグロビン),マンモス(3VRF,CO結合),シロザメ(1GCW,CO結合),チューブワーム(1YHU)
同 [2](何れもA鎖): ヒト(2HHB,デオキシヘモグロビン),ヤツメウナギ(2LHB,CN-結合),ヌタウナギ(1IT3,CO結合)
同 [3]: ヒト(2HHB),ウマ(6R2O)
同 [4]: ヒト(2HHB)・ウマ(6R2O)・オオカミ(タテガミオオカミ,1FHJ)・イヌ(グレイハウンド,3PEL);何れもA鎖
→ アミノ酸配列比較 | Jmolトピック(明石書店「飼いならす」)
同 [5]: サツマハオリムシ(3WCT;24量体,Chain A-H × 3)
【参考(サツマハオリムシ研究例)】 鹿児島湾の奇妙な生き物 サツマハオリムシの全ゲノムを解読 ―化学合成生態系への適応メカニズムに迫る―(東京大学,2023/06/26) [NEW!]
※プレスリリース中の“Toll様受容体(TLR)”についてはToll様受容体参照
同 [6]: 細菌Vitreoscilla stercoraria由来ヘモグロビン(2VHBのA鎖,アジ化物イオンが結合)とそのPDBsumデータ
ヒト | Val | Leu | Ser | Pro | Ala | Asp | Lys | Thr | Asn | Val | Lys | Ala | Ala | Trp | Gly | Lys | Val | Gly | Ala | His | Ala | Gly | Glu | Tyr | Gly | Ala | Glu | Ala | Leu | Glu | Arg | Met | Phe | Leu | Ser | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Leu | Ser | His |
ヒト B鎖 | Val | His | Leu | Thr | Pro | Glu | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
ヒト胎児HbF B鎖 ** | Val | His | Phe | Thr | Glu | Glu | Asp | Lys | Ala | Thr | Ile | Thr | Ser | Leu | Trp | Gly | Lys | Val | Asn | Val | Glu | Asp | Ala | Gly | Gly | Glu | Thr | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Asp | Ser | Phe | Gly | Asn | Leu | Ser | Ser |
マンモス | Val | Leu | Ser | Asp | Asn | Asp | Lys | Thr | Asn | Val | Lys | Ala | Thr | Trp | Ser | Lys | Val | Gly | Asp | His | Ala | Ser | Asp | Tyr | Val | Ala | Glu | Ala | Leu | Glu | Arg | Met | Phe | Phe | Ser | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Leu | Ser | His |
ハツカネズミ | Val | Leu | Ser | Gly | Glu | Asp | Lys | Ser | Asn | Ile | Lys | Ala | Ala | Trp | Gly | Lys | Ile | Gly | Gly | His | Gly | Ala | Glu | Tyr | Gly | Ala | Glu | Ala | Leu | Glu | Arg | Met | Phe | Ala | Ser | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Val | Ser | His |
ウズラ | Val | Leu | Ser | Ala | Ala | Asp | Lys | Thr | Asn | Val | Lys | Gly | Ile | Phe | Ala | Lys | Ile | Ala | Gly | His | Ala | Glu | Glu | Tyr | Gly | Ala | Glu | Ala | Leu | Asp | Arg | Met | Phe | Thr | Thr | Tyr | Pro | Gln | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Val | Ser | His |
クロマグロ | Thr | Thr | Leu | Ser | Asp | Lys | Asp | Lys | Ser | Thr | Val | Lys | Ala | Leu | Trp | Gly | Lys | Ile | Ser | Lys | Ser | Ala | Asp | Ala | Ile | Gly | Ala | Asp | Ala | Leu | Gly | Arg | Met | Leu | Ala | Val | Tyr | Pro | Gln | Thr | Lys | Thr | Tyr | Phe | Ser | His | Trp | Pro | Asp | |
シロザメ | Ala | Phe | Thr | Ala | Cys | Glu | Lys | Gln | Thr | Ile | Gly | Lys | Ile | Ala | Gln | Val | Leu | Ala | Lys | Ser | Pro | Glu | Ala | Tyr | Gly | Ala | Glu | Cys | Leu | Ala | Arg | Leu | Phe | Val | Thr | His | Pro | Gly | Ser | Lys | Ser | Tyr | Phe | Glu | Tyr | Lys | Asp | Tyr | Ser | Ala |
ヤツメウナギ | Pro | Ile | Val | Asp | Thr | Gly | Ser | Val | Ala | Pro | Leu | Ser | Ala | Ala | Glu | Lys | Thr | Lys | Ile | Arg | Ser | Ala | Trp | Ala | Pro | Val | Tyr | Ser | Thr | Tyr | Glu | Thr | Ser | Gly | Val | Asp | Ile | Leu | Val | Lys | Phe | Phe | Thr | Ser | Thr | Pro | Ala | Ala | Gln | Glu |
ヌタウナギ | Pro | Ile | Ile | Asp | Gln | Gly | Pro | Leu | Pro | Thr | Leu | Thr | Asp | Gly | Asp | Lys | Lys | Ala | Ile | Asn | Lys | Ile | Trp | Pro | Lys | Ile | Tyr | Lys | Glu | Tyr | Glu | Gln | Tyr | Ser | Leu | Asn | Ile | Leu | Leu | Arg | Phe | Leu | Lys | Cys | Phe | Pro | Gln | Ala | Gln | Ala |
チューブワーム | Ala | Cys | Ala | Met | Leu | Glu | Arg | Ala | Lys | Val | Lys | Asp | Glu | Trp | Ala | Lys | Ala | Tyr | Gly | Ile | Gly | Ala | Ala | Arg | Ser | Lys | Phe | Gly | Asp | Ala | Leu | Trp | Arg | Asn | Val | Phe | Asn | Tyr | Ala | Pro | Asn | Ala | Arg | Asp | Ile | Phe | Glu | Ser | Val | Asn |
サツマハオリムシ | Asp | Cys | Asn | Ile | Leu | Gln | Arg | Leu | Lys | Val | Lys | Met | Gln | Trp | Ala | Lys | Ala | Tyr | Gly | Phe | Gly | Thr | Glu | Arg | Ala | Lys | Phe | Gly | Asn | Ser | Leu | Trp | Thr | Ser | Ile | Phe | Asn | Tyr | Ala | Pro | Asp | Ala | Arg | Asp | Leu | Phe | Lys | Ser | Val | Lys |
マシコヒゲムシ | Val | Cys | Asn | Arg | Leu | Glu | Gln | Ile | Leu | Val | Lys | Thr | Gln | Trp | Ala | Gln | Ser | Tyr | Gly | Glu | Ala | Glu | Asn | Arg | Ala | Ala | Phe | Ser | Arg | Asp | Leu | Phe | Ser | Glu | Leu | Phe | Asn | Ile | Gln | Gly | Ser | Ser | Arg | Ala | Leu | Phe | Ser | Gly | Val | Gly |
ヒト | Gly | Ser | Ala | Gln | Val | Lys | Gly | His | Gly | Lys | Lys | Val | Ala | Asp | Ala | Leu | Thr | Asn | Ala | Val | Ala | His | Val | Asp | Asp | Met | Pro | Asn | Ala | Leu | Ser | Ala | Leu | Ser | Asp | Leu | His | Ala | His | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu |
ヒト B鎖 | Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
ヒト胎児HbF B鎖 ** | Ala | Ser | Ala | Ile | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Thr | Ser | Leu | Gly | Asp | Ala | Ile | Lys | His | Leu | Asp | Asp | Leu | Lys | Gly | Thr | Phe | Ala | Gln | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
マンモス | Gly | Ser | Gly | Gln | Val | Lys | Gly | His | Gly | Lys | Lys | Val | Gly | Glu | Ala | Leu | Thr | Gln | Ala | Val | Gly | His | Leu | Asp | Asp | Leu | Pro | Ser | Ala | Leu | Ser | Ala | Leu | Ser | Asp | Leu | His | Ala | His | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu |
ハツカネズミ | Gly | Ser | Ala | Gln | Val | Lys | Gly | His | Gly | Lys | Lys | Val | Ala | Asp | Ala | Leu | Ala | Ser | Ala | Ala | Gly | His | Leu | Asp | Asp | Leu | Pro | Gly | Ala | Leu | Ser | Ala | Leu | Ser | Asp | Leu | His | Ala | His | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu |
ウズラ | Gly | Ser | Ala | Gln | Ile | Lys | Gly | His | Gly | Lys | Lys | Val | Ala | Ala | Ala | Leu | Val | Glu | Ala | Ala | Asn | His | Ile | Asp | Asp | Ile | Ala | Gly | Thr | Leu | Ser | Lys | Leu | Ser | Asp | Leu | His | Ala | Gln | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu |
クロマグロ | Met | Ser | Pro | Gly | Ser | Gly | Pro | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Met | Gly | Gly | Val | Ala | Leu | Ala | Val | Ser | Lys | Ile | Asp | Asp | Leu | Thr | Thr | Gly | Leu | Gly | Asp | Leu | Ser | Glu | Leu | His | Ala | Phe | Lys | Met | Arg | Val | Asp | Pro | Ser | Asn |
シロザメ | Ala | Gly | Ala | Lys | Val | Gln | Val | His | Gly | Gly | Lys | Val | Ile | Arg | Ala | Val | Val | Lys | Ala | Ala | Glu | His | Val | Asp | Asp | Leu | His | Ser | His | Leu | Glu | Thr | Leu | Ala | Leu | Thr | His | Gly | Lys | Lys | Leu | Leu | Val | Asp | Pro | Gln | Asn | Phe | Pro | Met |
ヤツメウナギ | Phe | Phe | Pro | Lys | Phe | Lys | Gly | Leu | Thr | Thr | Ala | Asp | Glu | Leu | Lys | Lys | Ser | Ala | Asp | Val | Arg | Trp | His | Ala | Glu | Arg | Ile | Ile | Asn | Ala | Val | Asp | Asp | Ala | Val | Ala | Ser | Met | Asp | Asp | Thr | Glu | Lys | Met | Ser | Met | Lys | Leu | Arg | Asn |
ヌタウナギ | Ser | Phe | Pro | Lys | Phe | Ser | Thr | Lys | Lys | Ser | Asn | Leu | Glu | Gln | Asp | Pro | Glu | Val | Lys | His | Gln | Ala | Val | Val | Ile | Phe | Asn | Lys | Val | Asn | Glu | Ile | Ile | Asn | Ser | Met | Asp | Asn | Gln | Glu | Glu | Ile | Ile | Lys | Ser | Leu | Lys | Asp | Leu | Ser |
チューブワーム | Ser | Lys | Asp | Met | Ala | Ser | Pro | Glu | Phe | Lys | Ala | His | Ile | Ala | Arg | Val | Leu | Gly | Gly | Leu | Asp | Arg | Val | Ile | Ser | Met | Leu | Asp | Asn | Gln | Ala | Thr | Leu | Asp | Ala | Asp | Leu | Ala | His | Leu | Lys | Ser | Gln | His | Asp | Pro | Arg | Thr | Ile | Asp |
サツマハオリムシ | Ser | Glu | Asp | Met | Arg | Ser | Pro | Gln | Phe | Lys | Ala | His | Ile | Ala | Arg | Val | Ile | Gly | Gly | Leu | Asp | Arg | Val | Ile | Ser | Met | Phe | Asp | Asn | Glu | Asp | Ala | Leu | Asn | Ala | Asp | Leu | Glu | His | Leu | Lys | Ser | Gln | His | Asp | Pro | Arg | Gly | Leu | Asp |
マシコヒゲムシ | Val | Asp | Asp | Met | Asn | Ser | Ala | Ala | Phe | Thr | Ala | His | Cys | Leu | Arg | Val | Thr | Gly | Ala | Leu | Asn | Arg | Leu | Ile | Ser | Gln | Leu | Asp | Gln | Gln | Ala | Thr | Ile | Asn | Ala | Asp | Leu | Ala | His | Leu | Ala | Gly | Gln | His | Ala | Ser | Arg | Asn | Leu | Asp |
ヒト | Leu | Ser | His | Cys | Leu | Leu | Val | Thr | Leu | Ala | Ala | His | Leu | Pro | Ala | Glu | Phe | Thr | Pro | Ala | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Leu | Ala | Ser | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg | ||||||||
ヒト B鎖 | Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His | ヒト胎児HbF B鎖 ** | Glu | Asn | Phe | Lys | Leu | Leu | Gly | Asn | Val | Leu | Val | Thr | Val | Leu | Ala | Ile | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Glu | Val | Gln | Ala | Ser | Trp | Gln | Lys | Met | Val | Thr | Gly | Val | Ala | Ser | Ala | Leu | Ser | Ser | Arg | Tyr | His |
マンモス | Leu | Ser | His | Cys | Leu | Leu | Val | Thr | Leu | Ser | Ser | His | Gln | Pro | Thr | Glu | Phe | Thr | Pro | Glu | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Leu | Ser | Asn | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg | ||||||||
ハツカネズミ | Leu | Ser | His | Cys | Leu | Leu | Val | Thr | Leu | Ala | Ser | His | His | Pro | Ala | Asp | Phe | Thr | Pro | Ala | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Leu | Ala | Ser | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg | ||||||||
ウズラ | Leu | Gly | Gln | Cys | Phe | Leu | Val | Val | Val | Ala | Ile | His | His | Pro | Ala | Ala | Leu | Thr | Pro | Glu | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Leu | Cys | Ala | Val | Gly | Thr | Val | Leu | Thr | Ala | Lys | Tyr | Arg | ||||||||
クロマグロ | Phe | Lys | Ile | Leu | Ser | His | Cys | Ile | Leu | Val | Val | Val | Ala | Lys | Met | Phe | Pro | Lys | Glu | Phe | Thr | Pro | Asp | Ala | His | Val | Ser | Leu | Asp | Lys | Phe | Leu | Ala | Ser | Val | Ala | Leu | Ala | Leu | Ala | Glu | Arg | Tyr | Arg | |||||
シロザメ | Leu | Ser | Glu | Cys | Ile | Ile | Val | Thr | Leu | Ala | Thr | His | Leu | Thr | Glu | Phe | Ser | Pro | Asp | Thr | His | Cys | Ala | Val | Asp | Lys | Leu | Leu | Ser | Ala | Ile | Cys | Gln | Glu | Leu | Ser | Ser | Arg | Tyr | Arg | |||||||||
ヤツメウナギ | Leu | Ser | Gly | Lys | His | Ala | Lys | Ser | Phe | Gln | Val | Asp | Pro | Glu | Tyr | Phe | Lys | Val | Leu | Ala | Ala | Val | Ile | Ala | Asp | Thr | Val | Ala | Ala | Gly | Asp | Ala | Gly | Phe | Glu | Lys | Leu | Met | Ser | Met | Ile | Cys | Ile | Leu | Leu | Arg | Ser | Ala | Tyr |
ヌタウナギ | Gln | Lys | His | Lys | Thr | Val | Phe | Lys | Val | Asp | Ser | Ile | Trp | Phe | Lys | Glu | Leu | Ser | Ser | Ile | Phe | Val | Ser | Thr | Ile | Asp | Gly | Gly | Ala | Glu | Phe | Glu | Lys | Leu | Phe | Ser | Ile | Ile | Cys | Ile | Leu | Leu | Arg | Ser | Ala | Tyr | |||
チューブワーム | Pro | Val | Asn | Phe | Val | Val | Phe | Arg | Lys | Ala | Leu | Ile | Ala | Thr | Val | Ala | Gly | Thr | Phe | Gly | Val | Cys | Phe | Asp | Val | Pro | Ala | Trp | Gln | Gly | Cys | Tyr | Asn | Ile | Ile | Ala | Lys | Gly | Ile | Thr | Gly | Ser | Asp | Ala | Ala | ||||
サツマハオリムシ | Ala | Leu | Asn | Phe | Val | Val | Phe | Gly | Lys | Ala | Leu | Phe | Ala | Thr | Val | Gly | Gly | Gln | Phe | Gly | Val | Cys | Phe | Asp | Leu | Pro | Ala | Trp | Glu | Ser | Cys | Tyr | Lys | Val | Ile | Ala | Met | Gly | Ile | Thr | Gly | Asn | Asp | Met | Phe | Ser | |||
マシコヒゲムシ | Ala | Ser | Asn | Phe | Ala | Ala | Met | Gly | Gln | Ala | Val | Met | Ser | Val | Val | Pro | Thr | His | Leu | Asp | Cys | Phe | Asn | Gln | His | Ala | Trp | Gly | Glu | Cys | Tyr | Glu | Arg | Ile | Ala | Ser | Gly | Ile | Ser | Gly |
1-50 | ヒト(2HHB) | Val | Leu | Ser | Pro | Ala | Asp | Lys | Thr | Asn | Val | Lys | Ala | Ala | Trp | Gly | Lys | Val | Gly | Ala | His | Ala | Gly | Glu | Tyr | Gly | Ala | Glu | Ala | Leu | Glu | Arg | Met | Phe | Leu | Ser | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Leu | Ser | His |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ウマ(6R2O) | Val | Leu | Ser | Ala | Ala | Asp | Lys | Thr | Asn | Val | Lys | Ala | Ala | Trp | Ser | Lys | Val | Gly | Gly | His | Ala | Gly | Glu | Tyr | Gly | Ala | Glu | Ala | Leu | Glu | Arg | Met | Phe | Leu | Gly | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Leu | Ser | His | |
オオカミ(1FHJ) | Val | Leu | Ser | Pro | Ala | Asp | Lys | Thr | Asn | Ile | Lys | Ser | Thr | Trp | Asp | Lys | Ile | Gly | Gly | His | Ala | Gly | Asp | Tyr | Gly | Gly | Glu | Ala | Leu | Asp | Arg | Thr | Phe | Gln | Ser | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Leu | Ser | Pro | |
イヌ(3PEL) | Val | Leu | Ser | Pro | Ala | Asp | Lys | Thr | Asn | Ile | Lys | Ser | Thr | Trp | Asp | Lys | Ile | Gly | Gly | His | Ala | Gly | Asp | Tyr | Gly | Gly | Glu | Ala | Leu | Asp | Arg | Thr | Phe | Gln | Ser | Phe | Pro | Thr | Thr | Lys | Thr | Tyr | Phe | Pro | His | Phe | Asp | Leu | Ser | Pro | |
50-100 | ヒト(2HHB) | Gly | Ser | Ala | Gln | Val | Lys | Gly | His | Gly | Lys | Lys | Val | Ala | Asp | Ala | Leu | Thr | Asn | Ala | Val | Ala | His | Val | Asp | Asp | Met | Pro | Asn | Ala | Leu | Ser | Ala | Leu | Ser | Asp | Leu | His | Ala | His | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu |
ウマ(6R2O) | Gly | Ser | Ala | Gln | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Gly | Asp | Ala | Leu | Thr | Leu | Ala | Val | Gly | His | Leu | Asp | Asp | Leu | Pro | Gly | Ala | Leu | Ser | Asn | Leu | Ser | Asp | Leu | His | Ala | His | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu | |
オオカミ(1FHJ) | Gly | Ser | Ala | Gln | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Ala | Asp | Ala | Leu | Thr | Thr | Ala | Val | Ala | His | Leu | Asp | Asp | Leu | Pro | Gly | Ala | Leu | Ser | Ala | Leu | Ser | Asp | Leu | His | Ala | Tyr | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu | |
イヌ(3PEL) | Gly | Ser | Ala | Gln | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Ala | Asp | Ala | Leu | Thr | Thr | Ala | Val | Ala | His | Leu | Asp | Asp | Leu | Pro | Gly | Ala | Leu | Ser | Ala | Leu | Ser | Asp | Leu | His | Ala | Tyr | Lys | Leu | Arg | Val | Asp | Pro | Val | Asn | Phe | Lys | Leu | |
100- | ヒト(2HHB) | Leu | Ser | His | Cys | Leu | Leu | Val | Thr | Leu | Ala | Ala | His | Leu | Pro | Ala | Glu | Phe | Thr | Pro | Ala | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Leu | Ala | Ser | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg | |||||||||
ウマ(6R2O) | Leu | Ser | His | Cys | Leu | Leu | Ser | Thr | Leu | Ala | Val | His | Leu | Pro | Asn | Asp | Phe | Thr | Pro | Ala | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Leu | Ser | Ser | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg | ||||||||||
オオカミ(1FHJ) | Leu | Ser | His | Cys | Leu | Leu | Val | Thr | Leu | Ala | Cys | His | His | Pro | Thr | Glu | Phe | Thr | Pro | Ala | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Phe | Thr | Ala | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg | ||||||||||
イヌ(3PEL) | Leu | Ser | His | Cys | Leu | Leu | Val | Thr | Leu | Ala | Cys | His | His | Pro | Thr | Glu | Phe | Thr | Pro | Ala | Val | His | Ala | Ser | Leu | Asp | Lys | Phe | Phe | Ala | Ala | Val | Ser | Thr | Val | Leu | Thr | Ser | Lys | Tyr | Arg |
Met | Glu | Ser | Glu | Gly | Lys | Ile | Val | Phe | Thr | Glu | Glu | Gln | Glu | Ala | Leu | Val | Val | Lys | Ser | Trp | Ser | Val | Met | Lys | Lys | Asn | Ser | Ala | Glu | Leu | Gly | Leu | Lys | Leu | Phe | Ile | Lys | Ile | Phe | Glu | Ile | Ala | Pro | Thr | Thr | Lys | Lys | Met | Phe |
Ser | Phe | Leu | Arg | Asp | Ser | Pro | Ile | Pro | Ala | Glu | Gln | Asn | Pro | Lys | Leu | Lys | Pro | His | Ala | Met | Ser | Val | Phe | Val | Met | Cys | Cys | Glu | Ser | Ala | Val | Gln | Leu | Arg | Lys | Thr | Gly | Lys | Val | Thr | Val | Arg | Glu | Thr | Thr | Leu | Lys | Arg | Leu |
Gly | Ala | Ser | His | Ser | Lys | Tyr | Gly | Val | Val | Asp | Glu | His | Phe | Glu | Val | Ala | Lys | Tyr | Ala | Leu | Leu | Glu | Thr | Ile | Lys | Glu | Ala | Val | Pro | Glu | Met | Trp | Ser | Pro | Glu | Met | Lys | Val | Ala | Trp | Gly | Gln | Ala | Tyr | Asp | His | Leu | Val | Ala |
Ala | Ile | Lys | Ala | Glu | Met | Asn | Leu | Ser | Asn |
Ala | Phe | Val | Gly | Leu | Ser | Asp | Ser | Glu | Glu | Lys | Leu | Val | Arg | Asp | Ala | Trp | Ala | Pro | Ile | His | Gly | Asp | Leu | Gln | Gly | Thr | Ala | Asn | Thr | Val | Phe | Tyr | Asn | Tyr | Leu | Lys | Lys | Tyr | Pro | Ser | Asn | Gln | Asp | Lys | Phe | Glu | Thr | Leu | Lys |
Gly | His | Pro | Leu | Asp | Glu | Val | Lys | Asp | Thr | Ala | Asn | Phe | Lys | Leu | Ile | Ala | Gly | Arg | Ile | Phe | Thr | Ile | Phe | Asp | Asn | Cys | Val | Lys | Asn | Val | Gly | Asn | Asp | Lys | Gly | Phe | Gln | Lys | Val | Ile | Ala | Asp | Met | Ser | Gly | Pro | His | Val | Ala |
Arg | Pro | Ile | Thr | His | Gly | Ser | Tyr | Asn | Asp | Leu | Arg | Gly | Val | Ile | Tyr | Asp | Ser | Met | His | Leu | Asp | Ser | Thr | His | Gly | Ala | Ala | Trp | Asn | Lys | Met | Met | Asp | Asn | Phe | Phe | Tyr | Val | Phe | Tyr | Glu | Cys | Leu | Asp | Gly | Arg | Cys | Ser | Gln |
Phe | Ser |
【参考】ヘモグロビンとヘモグロビンS
VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLST
VHLTPVEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLST
※以下にこの配列について,1文字アミノ酸配列から各種HTMLデータを作成する秀丸マクロ により処理したデータを示す。
4HHB(アミノ酸別着色)
4hhbと2hbsのアミノ酸配列の違い(FASTA Sequence,何れもB鎖について)
※赤字が最初の共通開始部分トップのMet
4HHB:B|PDBID|CHAIN|SEQUENCE
PDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDP
ENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
2HBS:B|PDBID|CHAIN|SEQUENCE
PDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDP
ENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
Val | His | Leu | Thr | Pro | Glu | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
Val | His | Leu | Thr | Pro | Val | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
Val | His | Leu | Thr | Pro | Glu | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
Val | His | Leu | Thr | Pro | Val | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
4HHB(I/O値順)
Val | His | Leu | Thr | Pro | Glu | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
Val | His | Leu | Thr | Pro | Val | Glu | Lys | Ser | Ala | Val | Thr | Ala | Leu | Trp | Gly | Lys | Val | Asn | Val | Asp | Glu | Val | Gly | Gly | Glu | Ala | Leu | Gly | Arg | Leu | Leu | Val | Val | Tyr | Pro | Trp | Thr | Gln | Arg | Phe | Phe | Glu | Ser | Phe | Gly | Asp | Leu | Ser | Thr |
Pro | Asp | Ala | Val | Met | Gly | Asn | Pro | Lys | Val | Lys | Ala | His | Gly | Lys | Lys | Val | Leu | Gly | Ala | Phe | Ser | Asp | Gly | Leu | Ala | His | Leu | Asp | Asn | Leu | Lys | Gly | Thr | Phe | Ala | Thr | Leu | Ser | Glu | Leu | His | Cys | Asp | Lys | Leu | His | Val | Asp | Pro |
Glu | Asn | Phe | Arg | Leu | Leu | Gly | Asn | Val | Leu | Val | Cys | Val | Leu | Ala | His | His | Phe | Gly | Lys | Glu | Phe | Thr | Pro | Pro | Val | Gln | Ala | Ala | Tyr | Gln | Lys | Val | Val | Ala | Gly | Val | Ala | Asn | Ala | Leu | Ala | His | Lys | Tyr | His |
《話題》 オキシヘモグロビン・デオキシヘモグロビンとfMRI
fMRI(機能的磁気共鳴画像)は脳の活動を調べる神経活動計測法の一つであるが,その測定原理となっているのが,オキシヘモグロビンとデオキシヘモグロビンの磁性体としての性質の差である。
デオキシヘモグロビンの方が常磁性体としての性質をもつので,MRIの強い磁場の中において磁場を乱してMRI信号を減弱させる(Blood oxygen level dependent効果,BOLD効果)。ところが脳の活動が活発化して,網細血管にオキシヘモグロビンが流入するとMRI信号を弱めていたデオキシヘモグロビンが押し出されて信号強度が回復する。この現象による局所的なシグナルの強弱を測定して脳の活動状態を調べるのである。
参考
参考文献・Webページ
※ハオリムシ(チューブワーム),ヒゲムシについて。“ヒトヘモグロビンは赤血球細胞内では極めて高い濃度で存在するが、もし、それらが血管中に溶解し濃度が薄くなると(具体的には約50μM以下)、α2β2の4次構造が崩壊し、ヘモグロビンとしての機能を失うことが知られている。有鬚動物巨大ヘモグロビンが血管中でヘモグロビンとして機能するためには、どんなに薄い濃度でも4量体構造を保持することが必要であり、そのために多量体化しているのかもしれない”。
3D印刷技術を応用した新たな分子模型の作製方法を開発(JAIST,2012/08/06)
※同分子模型に関する資料はこちらをご覧ください。
メチル水銀の主要キャリアとされるグルタチオン,ヘモグロビン例1hho,血清アルブミン例1e7i
(S原子を大きく表示,図のクリックで拡大)